Hot on the heels of v12.5.2 on October 28, Apple has released iTunes 12.5.3. The description
in the App Store app is the same as the previous version, so perhaps there are just additional "stability and performance improvements" that were caught over the weekend.
[UPDATE: The 12.5.3 release is apparently for Mac OS X 10.11 and macOS 10.12 only.]
[UPDATE ALSO: Curiously, after I originally updated to 22.214.171.124, the App Store app notified me of another 12.5.3 update about a day later. This turned out to be version 126.96.36.199. Just sayin'.]